Chan, MichelleSmith, ZacharyEgli, DieterRegev, AvivMeissner, Alexander2014-02-192012Chan, Michelle M., Zachary D. Smith, Dieter Egli, Aviv Regev, and Alexander Meissner. 2012. Mouse ooplasm confers context-specific reprogramming capacity. Nature Genetics 44(9): 978-980.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:11722992Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer such as germ-line associated promoters, as well as unique limitations that include certain repetitive element classes.en-USJournal Article2014-02-1910.1038/ng.2382