Zhang, Jing-ShuLi, Da-MingMa, YueHe, NingGu, QingWang, Feng-ShanJiang, Shu-QingChen, Bing-QingLiu, Jia-Ren2013-05-082013Zhang, Jing-Shu, Da-Ming Li, Yue Ma, Ning He, Qing Gu, Feng-Shan Wang, Shu-Qing Jiang, Bing-Qing Chen, and Jia-Ren Liu. 2013. γ-tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. PLoS ONE 8(2): e57779.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:10612557Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells. We showed that treatment with different concentrations of γ-tocotrienol resulted in a dose dependent inhibition of cell growth. Cell death induced by γ-tocotrienol was mediated by a paraptosis-like cell death in SW620 and HCT-8 cells. Real-time RT-PCR and western blot analyses showed that γ-tocotrienol inhibited the expression level of β-catenin, cyclin D1 and c-jun. These data suggest that a paraptosis-like cell death induced by γ-tocotrienol in SW620 cells is associated with the suppression of the Wnt signaling pathway, which offers a novel tool for treating apoptosis-resistance colon cancer.en-USBiologyBiochemistryLipidsLipid MediatorsMolecular Cell BiologySignal TransductionSignaling in Cellular ProcessesLipid SignalingCell GrowthToxicologyToxic AgentsMedicineGastroenterology and HepatologyColonNutritionMicronutrient DeficienciesVitaminsOncologyCancers and NeoplasmsGastrointestinal TumorsColon AdenocarcinomaJournal Article2013-05-0810.1371/journal.pone.0057779