Ichimura, TakaharuBrooks, Craig R.Bonventre, Joseph2013-04-232012Ichimura, Takaharu, Craig Brooks, and Joseph Vincent Bonventre. 2012. Kim-1/Tim-1 and immune cells: Shifting sands. Kidney International 81(9): 809-811.0085-25381523-1755http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579389Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.en-USJournal Article2013-04-2310.1038/ki.2012.11