Narayan, KavithaSylvia, Katelyn E.Malhotra, NidhiYin, Catherine C.Martens, GregoryVallerskog, ThereseKornfeld, HardyXiong, NaCohen, NadiaBrenner, MichaelBerg, Leslie J.Kang, Joonsoo2013-04-222012Narayan, Kavitha, Katelyn E. Sylvia, Nidhi Malhotra, Catherine C. Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. 2012. Intrathymic programming of effector fates in three molecularly distinct γδ t cell subtypes. Nature Immunology 13(5): 511-518.1529-2908http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579384γδ T cells function in the early phase of immune responses. Although innate γδ T cells have primarily been studied as one homogenous population, they can be functionally classified into effector subsets based on the production of signature cytokines, analogous to adaptive T helper subsets. Unlike adaptive T cells, however, γδ T effector function correlates with genomically encoded TCR chains, suggesting that clonal TCR selection is not the primary determinant of γδ effector differentiation. A high resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated based on TCRγ/δ chain usage indicates the existence of three separate subtypes of γδ effectors in the thymus. The immature γδ subsets are distinguished by unique transcription factor modules that program effector function.en-USJournal Article2013-04-2210.1038/ni.2247