Perez, FreddyEngelsmann, BarbaraMushavi, AngelaRusibamayila, AsinathKeatinge, JoPark, Ji-EunMaruva, MatthewsWood, RobinDabis, FrancoisCiaranello, AndreaWalensky, RochelleCerda, RodrigoFreedberg, Kenneth2013-05-092012Ciaranello, Andrea Lynne, Freddy Perez, Barbara Engelsmann, Rochelle P. Walensky, Angela Mushavi, Asinath Rusibamayila, Jo Keatinge, et al. 2012. Cost-effectiveness of World Health Organization 2010 guidelines for prevention of mother-to-child HIV transmission in Zimbabwe. Clinical Infectious Diseases 56(3): 430-446.1058-48381537-6591http://nrs.harvard.edu/urn-3:HUL.InstRepos:10613638Background. In 2010, the World Health Organization (WHO) released revised guidelines for prevention of mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). We projected clinical impacts, costs, and cost-effectiveness of WHO-recommended PMTCT strategies in Zimbabwe. Methods. We used Zimbabwean data in a validated computer model to simulate a cohort of pregnant, HIV-infected women (mean age, 24 years; mean CD4 count, 451 cells/µL; subsequent 18 months of breastfeeding). We simulated guideline-concordant care for 4 PMTCT regimens: single-dose nevirapine (sdNVP); WHO-recommended Option A, WHO-recommended Option B, and Option B+ (lifelong maternal 3-drug antiretroviral therapy regardless of CD4). Outcomes included maternal and infant life expectancy (LE) and lifetime healthcare costs (2008 US dollars [USD]). Incremental cost-effectiveness ratios (ICERs, in USD per year of life saved [YLS]) were calculated from combined (maternal + infant) discounted costs and LE. Results. Replacing sdNVP with Option A increased combined maternal and infant LE from 36.97 to 37.89 years and would reduce lifetime costs from $5760 to $5710 per mother–infant pair. Compared with Option A, Option B further improved LE (38.32 years), and saved money within 4 years after delivery ($5630 per mother–infant pair). Option B+ (LE, 39.04 years; lifetime cost, $6620 per mother–infant pair) improved maternal and infant health, with an ICER of $1370 per YLS compared with Option B. Conclusions. Replacing sdNVP with Option A or Option B will improve maternal and infant outcomes and save money; Option B increases health benefits and decreases costs compared with Option A. Option B+ further improves maternal outcomes, with an ICER (compared with Option B) similar to many current HIV-related healthcare interventions.en-USHIVmother-to-child transmissionPMTCTpediatric HIVcost-effectivenessJournal Article2013-05-0910.1093/cid/cis858