Britton, KathrynPedley, AlisonMassaro, Joseph M.Corsini, Erin M.Murabito, Joanne M.Hoffmann, UdoFox, Caroline2013-05-132012Britton, Kathryn A., Alison Pedley, Joseph M. Massaro, Erin M. Corsini, Joanne M. Murabito, Udo Hoffmann, and Caroline S. Fox. 2012. Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study. Journal of the American Heart Association 1(6): e004200.2047-9980http://nrs.harvard.edu/urn-3:HUL.InstRepos:10623005Background: Thoracic periaortic adipose tissue (TAT) is associated with atherosclerosis and cardiovascular disease (CVD) risk factors and may play a role in obesity‐mediated vascular disease. We sought to determine the prevalence, distribution, and risk factor correlates of high TAT. Methods and Results: Participants from the Framingham Heart Study (n=3246, 48% women, mean age 51.1 years) underwent multidetector computed tomography; high TAT and visceral adipose tissue (VAT) were defined on the basis of sex‐specific 90th percentiles in a healthy referent sample. The prevalence of high TAT was 38.1% in women and 35.7% in men. Among individuals without high VAT, 10.1% had high TAT. After adjustment for age and VAT, both women and men with high TAT in the absence of high VAT were older and had a higher prevalence of CVD (P<0.0001) compared with those without high TAT. In addition, men in this group were more likely to be smokers (P=0.02), whereas women were more likely to have low high‐density lipoprotein cholesterol (P=0.005). Conclusions: Individuals in our community‐based sample with high TAT in the absence of high VAT were characterized by an adverse cardiometabolic profile. This adipose tissue phenotype may identify a subset of individuals with distinct metabolic characteristics.en-USEpidemiologybody fat distributionobesityperivascular adipose tissuerisk factorsvisceral adipose tissueJournal Article2013-05-1310.1161/JAHA.112.004200