Bogoch, IsaacAndrews, Jason RandolphZachary, KimonHohmann, Elizabeth2013-08-232013Bogoch, Isaac, Jason Randolph Andrews, Kimon C. Zachary, and Elizabeth Louise Hohmann. 2013. Diagnosis of influenza from lower respiratory tract sampling after negative upper respiratory tract sampling. Virulence 4(1): 82-84.2150-5594http://nrs.harvard.edu/urn-3:HUL.InstRepos:10978152In this retrospective cohort study, we demonstrate that PCR-confirmed diagnoses of influenza were made solely by lower respiratory sampling in 6.9% of cases, as traditional upper respiratory tract tests were negative, indeterminate or not performed. Clinical features of these cases are presented. Clinicians should consider lower respiratory tract sampling in select cases of influenza-like illness for diagnosis.en-USinfluenzahumanH1N1 virusbronchoalveolar lavagepolymerase chain reactionJournal Article2013-08-2310.4161/viru.22466