Morris, Andrew PVoight, Benjamin FTeslovich, Tanya MFerreira, TeresaSegré, Ayellet VSteinthorsdottir, ValgerdurStrawbridge, Rona JKhan, HassanGrallert, HaraldMahajan, AnubhaProkopenko, IngaKang, Hyun MinDina, ChristianEsko, TonuFraser, Ross MKanoni, StavroulaKumar, AshishLagou, VasilikiLangenberg, ClaudiaLuan, Jian’anLindgren, Cecilia MMüller-Nurasyid, MartinaPechlivanis, SonaliRayner, N WilliamScott, Laura JWiltshire, StevenYengo, LoicKinnunen, LeenaRossin, ElizabethRaychaudhuri, SoumyaJohnson, Andrew DDimas, Antigone SLoos, Ruth J FVedantam, SailajaChen, HanFlorez, JoseFox, CarolineLiu, Ching-TiRybin, DenisCouper, David JKao, Wen Hong LLi, ManCornelis, MarilynKraft, PeterSun, QiVan Dam, RobStringham, Heather MChines, Peter SFischer, KristaFontanillas, PierreHolmen, Oddgeir LHunt, Sarah EJackson, Anne UKong, AugustineLawrence, RobertMeyer, JuliaPerry, John R BPlatou, Carl G PPotter, SimonRehnberg, EmilRobertson, NeilSivapalaratnam, SutheshStančáková, AlenaStirrups, KathleenThorleifsson, GudmarTikkanen, EmmiWood, Andrew RAlmgren, PeterAtalay, MustafaBenediktsson, RafnBonnycastle, Lori LBurtt, NoëlCarey, JasonCharpentier, GuillaumeCrenshaw, Andrew TDoney, Alex S FDorkhan, MozhganEdkins, SarahEmilsson, ValurEury, ElodieForsen, TomGertow, KarlGigante, BrunaGrant, George BGroves, Christopher JGuiducci, CandaceHerder, ChristianHreidarsson, Astradur BHui, JennieJames, AlanJonsson, AnnaRathmann, WolfgangKlopp, NormanKravic, JasminaKrjutškov, KaarelLangford, CordeliaLeander, KarinLindholm, EeroLobbens, StéphaneMännistö, SatuMirza, GhazalaMühleisen, Thomas WMusk, BillParkin, Melissa AnnRallidis, LoukianosSaramies, JoukoSennblad, BengtShah, SoniaSigurðsson, GunnarSilveira, AngelaSteinbach, GeraldThorand, BarbaraTrakalo, JosephVeglia, FabrizioWennauer, RomanWinckler, WendyZabaneh, DelilahCampbell, Harryvan Duijn, CorneliaUitterlinden, Andre GHofman, AlbertSijbrands, EricAbecasis, Goncalo ROwen, Katharine RZeggini, EleftheriaTrip, Mieke DForouhi, Nita GSyvänen, Ann-ChristineEriksson, Johan GPeltonen, LeenaNöthen, Markus MBalkau, BeverleyPalmer, Colin N ALyssenko, ValeriyaTuomi, TiinamaijaIsomaa, BoHunter, DavidQi, LuShuldiner, Alan RRoden, MichaelBarroso, InesWilsgaard, TomBeilby, JohnHovingh, KeesPrice, Jackie FWilson, James FRauramaa, RainerLakka, Timo ALind, LarsDedoussis, GeorgeNjølstad, IngerPedersen, Nancy LKhaw, Kay-TeeWareham, Nicholas JKeinanen-Kiukaanniemi, Sirkka MSaaristo, Timo EKorpi-Hyövälti, EevaSaltevo, JuhaLaakso, MarkkuKuusisto, JohannaMetspalu, AndresCollins, Francis SMohlke, Karen LBergman, Richard NTuomilehto, JaakkoBoehm, Bernhard OGieger, ChristianHveem, KristianCauchi, StephaneFroguel, PhilippeBaldassarre, DamianoTremoli, ElenaHumphries, Steve ESaleheen, DanishDanesh, JohnIngelsson, ErikRipatti, SamuliSalomaa, VeikkoErbel, RaimundJöckel, Karl-HeinzMoebus, SusannePeters, AnnetteIllig, Thomasde Faire, UlfHamsten, AndersMorris, Andrew DDonnelly, Peter JFrayling, Timothy MHattersley, Andrew TBoerwinkle, EricMelander, OlleKathiresan, SekarNilsson, Peter MDeloukas, PanosThorsteinsdottir, UnnurGroop, Leif CStefansson, KariHu, FrankPankow, James SDupuis, JoséeMeigs, JamesAltshuler, DavidBoehnke, MichaelMcCarthy, Mark I2013-04-262012Morris, Andrew P., Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segré, Valgerdur Steinthorsdottir, Rona J. Strawbridge, et al. 2012. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics 44(9): 981-990.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:10589814To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis.en-USJournal Article2013-04-2610.1038/ng.2383