Segata, NicolaWaldron, LeviBallarini, AnnalisaNarasimhan, VagheeshJousson, OlivierHuttenhower, Curtis2013-12-112012Segata, Nicola, Levi Waldron, Annalisa Ballarini, Vagheesh Narasimhan, Olivier Jousson, and Curtis Huttenhower. 2012. Metagenomic microbial community profiling using unique clade-specific marker genes. Nature methods 9(8): 811-814.1548-7091http://nrs.harvard.edu/urn-3:HUL.InstRepos:11369874Metagenomic shotgun sequencing data can identify microbes populating a microbial community and their proportions, but existing taxonomic profiling methods are inefficient for increasingly large datasets. We present an approach that uses clade-specific marker genes to unambiguously assign reads to microbial clades more accurately and >50× faster than current approaches. We validated MetaPhlAn on terabases of short reads and provide the largest metagenomic profiling to date of the human guten-USJournal Article2013-12-1110.1038/nmeth.2066