Fontana, WalterMitchison, Timothy J.Romero, Catalina2013-10-182013-10-182013Romero, Catalina. 2013. Spatio-temporal control of the cytosolic redox environment in C. elegans. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11122http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181131Compartmentalization of redox reactions is essential to all life forms. Protein activity can respond to changes in the local redox environment through the reversible oxidation of cysteine thiols. For the majority of cysteines in the proteome, this interaction takes place through equilibration with the glutathione pool; this raises the question whether this redox pool acts as a buffer, or instead as a sensitive media, transducing information from a local physiological state into protein function.en-USMolecular biologyCellular biologyGeneticsagingC. elegansinsulin signalingoxidation reduction of proteinsredox potential of glutathione (GSH)spatial patterningThesis or Dissertation2015-10-10