I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis

Jacobsen, Eric N.Rajapaksa, Naomi Samadara2013-10-182013-10-182013Rajapaksa, Naomi Samadara. 2013. I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11127http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181228The research presented herein explores three aspects of asymmetric catalysis: (1) the development of new catalytic enantioselective reactions, (2) the application of stereoselective catalysis to natural product total synthesis, and (3) the design and synthesis of new chiral catalysts.en-USChemistryanion-abstractionbisthioureaenantioselectiveketone-enereserpineI. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction CatalysisThesis or Dissertation2013-10-18