Ribi, KAldridge, JPhillips, K-AThompson, AHarvey, VThürlimann, BCardoso, FPagani, OCoates, A SGoldhirsch, APrice, K NGelber, RichardBernhard, J2013-10-162012Ribi, K, J Aldridge, K-A Phillips, A Thompson, V Harvey, B Thürlimann, F Cardoso, et al. 2012. Subjective cognitive complaints one year after ceasing adjuvant endocrine treatment for early-stage breast cancer. British Journal of Cancer 106(10): 1618-1625.0007-0920http://nrs.harvard.edu/urn-3:HUL.InstRepos:11178965Background: In the BIG 1-98 trial objective cognitive function improved in postmenopausal women 1 year after cessation of adjuvant endocrine therapy for breast cancer. This report evaluates changes in subjective cognitive function (SCF). Methods: One hundred postmenopausal women, randomised to receive 5 years of adjuvant tamoxifen, letrozole, or a sequence of the two, completed self-reported measures on SCF, psychological distress, fatigue, and quality of life during the fifth year of trial treatment (year 5) and 1 year after treatment completion (year 6). Changes between years 5 and 6 were evaluated using the Wilcoxon signed-rank test. Subjective cognitive function and its correlates were explored. Results: Subjective cognitive function and the other patient-reported outcomes did not change significantly after cessation of endocrine therapy with the exception of improvement for hot flushes (P=0.0005). No difference in changes was found between women taking tamoxifen or letrozole. Subjective cognitive function was the only psychosocial outcome with a substantial correlation between year 5 and 6 (Spearman's R=0.80). Correlations between SCF and the other patient-reported outcomes were generally low. Conclusion: Improved objective cognitive function but not SCF occur following cessation of adjuvant endocrine therapy in the BIG 1-98 trial. The substantial correlation of SCF scores over time may represent a stable attribute.en-USsubjective cognitive functionquality of lifebreast canceraromatase inhibitortamoxifenletrozoleJournal Article2013-10-1610.1038/bjc.2012.156