Quirk, Michael C.Sosulski, Dara L.Feierstein, Claudia E.Uchida, NaoshigeMainen, Zachary F.2017-09-192009Quirk, Michael C., Dara L. Sosulski, Claudia E. Feierstein, Naoshige Uchida, and Zachary F. Mainen. 2009. A defined network of fast-spiking interneurons in orbitofrontal cortex: Responses to behavioral contingencies and ketamine administration. Frontiers in Systems Neuroscience 3. doi:10.3389/neuro.06.013.2009.1662-5137http://nrs.harvard.edu/urn-3:HUL.InstRepos:33907952Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC–FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.en-USschizophreniadepressionfast-spiking interneuronmotivationparvalbuminpsychosisJournal Article2013-07-09Michael C Quirk, Dara L Sosulski, Claudia E Feierstein, Naoshige Uchida, Zachary F Mainen2017-09-1910.3389/neuro.06.013.2009