Gaudet, Rachelle2013-11-132008Gaudet, Rachelle. 2008. TRP channels entering the structural era. The Journal of Physiology 586(15): 3565-3575.0022-3751http://nrs.harvard.edu/urn-3:HUL.InstRepos:11315436Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel gating and regulation. Two approaches have proven fruitful: (i) a divide-and-conquer strategy has provided high-resolution structural details of TRP channel fragments although it fails to explain how these fragments are integrated in the full channel; and (ii) electron microscopy of entire TRP channels has yielded low-resolution images that provide a basis for testable models of TRP channel architecture. The results of each approach, summarized in this review, provide a preview of what the future holds in TRP channel structural biology.en-USIon channelTRP channelelect ron microscopyx-ray crystallographyJournal Article2013-07-15Rachelle Gaudet2013-11-1310.1113/jphysiol.2008.155812