Hartl, Daniel L.Jiang, Pan-Pan2013-10-082013-10-082013Jiang, Pan-Pan. 2013. Patterns of molecular evolution and epistasis on a genomic and genic scale. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:10771http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808Epistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.en-USBiologyGeneticsEvolution & developmentdrug resistanceepistasisheterochromatinmalariaY chromosomeThesis or Dissertation2013-10-08