Garcia-Cardena, GuillermoSuo, ZhigangAdams, William2013-10-092013-10-082013Adams, William James. 2013. Human Vascular Endothelium from Induced Pluripotent Stem Cells. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:10816http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158273The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-derived endothelial cells remains poorly understood.en-USBiomedical engineeringCellular biologyendotheliuminduced pluripotent stem cellsThesis or Dissertation2015-06-08