Hahn, William C.Shao, Diane2013-10-152013-10-152013Shao, Diane Donghui. 2013. Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11076http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169824Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.en-USCellular biologyGeneticsATARiSHNF1BRASRNAiYAPThesis or Dissertation2015-10-10