Salic, AdrianNedelcu, Daniel2013-10-182013-10-182013Nedelcu, Daniel. 2013. Smoothened regulation in the Hedgehog signaling pathway. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11080http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181143Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane receptor, Patched. Patched normally inhibits the seven-spanner transmembrane protein Smoothened (Smo). Binding of Hedgehog inhibits Patched resulting in Smo derepression. Active Smo then triggers the activation of the cytoplasmic steps of the signaling pathway.en-USCellular biologyChemistryBiologyciliumcysteine-rich domainHedgehogoxysterolsSmoothenedThesis or Dissertation2013-10-18