Macklis, Jeffrey DanielSadegh, Cameron2013-10-182013-10-182013Sadegh, Cameron. 2013. Directed differentiation of mouse embryonic stem cells into neocortical output neurons. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11064http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181176During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons (CFuPN), is the primary output neuron population of the neocortex. CFuPN axons innervate sub-cortical targets including thalamus, striatum, brainstem, and spinal cord.en-USNeurosciencesDevelopmental biologyBiomedical engineeringCorticofugal projection neuronsCorticospinal motor neuronsDirected DifferentiationEmbryonic stem cellsNeocortexSynthetic modified RNAThesis or Dissertation2015-10-10