Zhang, YunChen, Zhunan2014-02-252014-02-252014Chen, Zhunan. 2014. Molecular and Circuit Mechanisms of Insulin Signaling in Caenorhabditis elegans. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11302http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744446Insulin signaling is highly conserved across animals, and is known for its ubiquitous function in all aspects of animal physiology. Despite its relatively well-studied role in metabolism and energy expenditure, how it is involved in learning and memory remains a mystery, due to the complex nature of the nervous system. In this thesis, I have used C. elegans, a tractable model organism with a sophisticated behavioral repertoire, to investigate molecular and cellular mechanisms of insulin signaling in learning.en-USBiologyC. elegansInsulinLearning BehaviorThesis or Dissertation