Chen, Vincent L.Surana, Neeraj K.Duan, JinyouKasper, Dennis2014-02-132013Chen, Vincent L., Neeraj K. Surana, Jinyou Duan, and Dennis L. Kasper. 2013. “Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection.” PLoS ONE 8 (6): e65405. doi:10.1371/journal.pone.0065405. http://dx.doi.org/10.1371/journal.pone.0065405.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708661Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome.en-USBiologyImmunologyImmune SystemCytokinesLymphoid OrgansImmunityImmune DefenseImmunity to InfectionsInnate ImmunityImmune ResponseMicrobiologyBacterial PathogensSalmonellaHost-Pathogen InteractionMicrobial EcologyModel OrganismsAnimal ModelsMouseJournal Article2014-02-1310.1371/journal.pone.0065405