Siddiqui, MeenaVakoc, Benjamin J.2014-02-182012Siddiqui, Meena, and Benjamin J. Vakoc. 2012. “Optical-domain subsampling for data efficient depth ranging in Fourier-domain optical coherence tomography.” Optics Express 20 (16): 17938-17951. doi:10.1364/OE.20.017938. http://dx.doi.org/10.1364/OE.20.017938.1094-4087http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717598Recent advances in optical coherence tomography (OCT) have led to higher-speed sources that support imaging over longer depth ranges. Limitations in the bandwidth of state-of-the-art acquisition electronics, however, prevent adoption of these advances into the clinical applications. Here, we introduce optical-domain subsampling as a method for imaging at high-speeds and over extended depth ranges but with a lower acquisition bandwidth than that required using conventional approaches. Optically subsampled laser sources utilize a discrete set of wavelengths to alias fringe signals along an extended depth range into a bandwidth limited frequency window. By detecting the complex fringe signals and under the assumption of a depth-constrained signal, optical-domain subsampling enables recovery of the depth-resolved scattering signal without overlapping artifacts from this bandwidth-limited window. We highlight key principles behind optical-domain subsampled imaging, and demonstrate this principle experimentally using a polygon-filter based swept-source laser that includes an intra-cavity Fabry-Perot (FP) etalon.en-USOptical coherence tomographyLasersJournal Article2014-02-1810.1364/OE.20.017938