Tsai, Tsung-HanPotsaid, BenjaminTao, Yuankai K.Jayaraman, VijaysekharJiang, JamesHeim, Peter J. S.Kraus, Martin F.Zhou, ChaoHornegger, JoachimMashimo, HiroshiCable, Alex E.Fujimoto, James G.2014-02-182013Tsai, T., B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, et al. 2013. “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology.” Biomedical Optics Express 4 (7): 1119-1132. doi:10.1364/BOE.4.001119. http://dx.doi.org/10.1364/BOE.4.001119.2156-7085http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717682We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.en-USOptical coherence tomographyMedical and biological imagingEndoscopic imagingGastrointestinalThree-dimensional image acquisitionFiber optics imagingScannersMedical optics instrumentationJournal Article2014-02-1810.1364/BOE.4.001119