Campbell, JamesNizza, Suzanne Josette Taghap2014-02-252014-02-252013Nizza, Suzanne Josette Taghap. 2014. The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11224http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744415Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing T cells. DCs process Ag for display to other immune cells, and stimulate T cells to release cytokines or directly lyse infected cells. Some T cells are further stimulated to express homing markers allowing them to enter non-lymphoid tissue such as the skin or the gut.en-USImmunologyCellular biologyBiologyDendritic cellsHoming markersSkin-homingSubsetsThesis or Dissertation2014-02-25