Arlotta, PaolaCepko, ConnieLin, Youshan Melissa2014-02-252014-02-252014Lin, Youshan Melissa. 2014. The role of Ppargc1álpha in neuronal survival and myelination in the neocortex. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11266http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744435The mammalian neocortex contains diverse neuronal and glial cell types. Among them lies an important subclass, the subcerebral projection neurons (SCPN) that project to distant targets like the spinal cord. Aiming at identifying molecular controls over the postnatal development of SCPN, I focus my investigations on the role of Ppargc1á because its function remains relatively unknown in the brain while it is important for metabolism and survival in other tissue systems.en-USNeurosciencesDevelopmental biologyBiologybrainmyelinneuronPpargc1álphasurvivalThesis or Dissertation2016-02-04