Verdine, Gregory L.Chu, Qian2014-02-252014-02-252013Chu, Qian. 2014. I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11278http://nrs.harvard.edu/urn-3:HUL.InstRepos:11745710Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two helical turns in a peptide increase alpha-helical content and protease resistance, enhance target binding affinity, and promote cell penetration. This technology has been applied to the development of cell-permeable ligands targeting several intracellular targets. This dissertation describes efforts to further the development of stapled peptide technology.en-USChemistryThesis or Dissertation2016-02-04