O’Donnell, Lauren J.Wells, WilliamGolby, AlexandraWestin, Carl-Fredrik2017-10-102012O’Donnell, Lauren J., William M. Wells, Alexandra J. Golby, and Carl-Fredrik Westin. 2012. “Unbiased Groupwise Registration of White Matter Tractography.” Lecture Notes in Computer Science: 123–130. doi:10.1007/978-3-642-33454-2_16.0302-9743http://nrs.harvard.edu/urn-3:HUL.InstRepos:34171140We present what we believe to be the first investigation into unbiased multi-subject registration of whole brain diffusion tractography of the white matter. To our knowledge, this is also the first entropy-based objective function applied to fiber tract registration. To define the probability of fiber trajectories for the computation of entropy, we take advantage of a pairwise fiber distance used as the basis for a Gaussian-like kernel. By employing several values of the kernel’s scale parameter, the method is inherently multi-scale. Results of experiments using synthetic and real datasets demonstrate the potential of the method for simultaneous joint registration of tractography.en-USregistration; white matter; tractography; diffusion MRIJournal Article2013-11-15O'Donnell LJ, Wells WM 3rd, Golby AJ, Westin CF2017-10-1010.1007/978-3-642-33454-2_16