Husain, ZaheedSeth, PankajSukhatme, Vikas2014-03-112013Husain, Zaheed, Pankaj Seth, and Vikas P Sukhatme. 2013. “Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology.” Oncoimmunology 2 (11): e26383. doi:10.4161/onci.26383. http://dx.doi.org/10.4161/onci.26383.2162-4011http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879577Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.en-USglycolysisketogenic dietlactateMDSCsNK cellsJournal Article2014-03-1110.4161/onci.26383