Paschalis, Eleftherios ICade, FabianoMelki, SamirPasquale, LouisDohlman, ClaesCiolino, Joseph2014-03-112014Paschalis, Eleftherios I, Fabiano Cade, Samir Melki, Louis R Pasquale, Claes H Dohlman, and Joseph B Ciolino. 2014. “Reliable intraocular pressure measurement using automated radio-wave telemetry.” Clinical Ophthalmology (Auckland, N.Z.) 8 (1): 177-185. doi:10.2147/OPTH.S54753. http://dx.doi.org/10.2147/OPTH.S54753.1177-5467http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879603Purpose To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and a motion sensor. Methods: The WIT optical aid was implanted within the ciliary sulcus of a normotensive rabbit eye after extracapsular clear lens extraction. An autonomous wireless data system (AWDS) comprising of a WIT and an external antenna aided by a motion sensor provided continuous IOP readings. The sensitivity of the technique was determined by the ability to detect IOP changes resulting from the administration of latanoprost 0.005% or dorzolamide 2%, while the reliability was determined by the agreement between baseline and vehicle (saline) IOP. Results: On average, 12 diurnal and 205 nocturnal IOP measurements were performed with latanoprost, and 26 diurnal and 205 nocturnal measurements with dorzolamide. No difference was found between mean baseline IOP (13.08±2.2 mmHg) and mean vehicle IOP (13.27±2.1 mmHg) (P=0.45), suggesting good measurement reliability. Both antiglaucoma medications caused significant IOP reduction compared to baseline; latanoprost reduced mean IOP by 10% (1.3±3.54 mmHg; P<0.001), and dorzolamide by 5% (0.62±2.22 mmHg; P<0.001). Use of latanoprost resulted in an overall twofold higher IOP reduction compared to dorzolamide (P<0.001). Repeatability was ±1.8 mmHg, assessed by the variability of consecutive IOP measurements performed in a short period of time (≤1 minute), during which the IOP is not expected to change. Conclusion: IOP measurements in conscious rabbits obtained without the need for human interactions using the AWDS are feasible and provide reproducible results.en-USIOPpressure transducerwirelessMEMSimplantintraocularJournal Article2014-03-1110.2147/OPTH.S54753