Savage, Sharon A.Mirabello, LisaWang, ZhaomingGastier-Foster, Julie M.Gorlick, RichardKhanna, ChandFlanagan, Adrienne M.Tirabosco, RobertoAndrulis, Irene L.Wunder, Jay S.Gokgoz, NalanPatiño-Garcia, AnaSierrasesúmaga, LuisLecanda, FernandoKurucu, NilgünIlhan, Inci ErgurhanSari, NerimanSerra, MassimoHattinger, ClaudiaPicci, PieroSpector, LoganBarkauskas, Donald A.Marina, Neyssade Toledo, Silvia Regina CaminadaPetrilli, Antonio S.Amary, Maria FernandaHalai, DinaThomas, David M.Douglass, ChesterMeltzer, Paul S.Jacobs, KevinChung, Charles C.Berndt, Sonja I.Purdue, Mark P.Caporaso, Neil E.Tucker, MargaretRothman, NathanielLandi, Maria TeresaSilverman, Debra T.Kraft, PhillipHunter, DavidMalats, NuriaKogevinas, ManolisWacholder, SholomTroisi, RebeccaHelman, LeeFraumeni, Joseph F.Yeager, MeredithHoover, Robert N.Chanock, Stephen J.2014-03-112013Savage, S. A., L. Mirabello, Z. Wang, J. M. Gastier-Foster, R. Gorlick, C. Khanna, A. M. Flanagan, et al. 2013. “Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma.” Nature genetics 45 (7): 799-803. doi:10.1038/ng.2645. http://dx.doi.org/10.1038/ng.2645.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879782Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10-9), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10-8 and 2.9 ×10-7). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.en-USJournal Article2014-03-1110.1038/ng.2645