Zhong, JunSharma, JyotiRaju, RajeshPalapetta, Shyam MohanPrasad, T. S. KeshavaHuang, Tai-ChungYoda, AkinoriTyner, Jeffrey W.van Bodegom, DiederikWeinstock, DavidZiegler, Steven F.Pandey, Akhilesh2014-03-112014Zhong, J., J. Sharma, R. Raju, S. M. Palapetta, T. S. K. Prasad, T. Huang, A. Yoda, et al. 2014. “TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.” Database: The Journal of Biological Databases and Curation 2014 (1): bau007. doi:10.1093/database/bau007. http://dx.doi.org/10.1093/database/bau007.1758-0463http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879894Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24en-USJournal Article2014-03-1110.1093/database/bau007