Rotstein, Benjamin H.Liang, StevenHolland, Jason PCollier, Thomas LHooker, JacobWilson, Alan A.Vasdev, Neil2014-04-252013Rotstein, Benjamin H., Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson, and Neil Vasdev. 2013. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications 49(50): 5621.1359-7345http://nrs.harvard.edu/urn-3:HUL.InstRepos:12111436Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.en-USJournal Article2014-04-2510.1039/c3cc42236d