Schönberger, MatthiasLeggett, CarmineKim, Sung WonHooker, Jacob2017-07-242010Schönberger, Matthias, Carmine Leggett, Sung Won Kim, and Jacob M. Hooker. 2010. “Synthesis of [11C]SSR149415 and Preliminary Imaging Studies Using Positron Emission Tomography.” Bioorganic & Medicinal Chemistry Letters 20 (10) (May): 3103–3106. doi:10.1016/j.bmcl.2010.03.108.0960-894Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33490459SSR149415 was the first non-peptide vasopressin-(V\(_{1b}\)) receptor antagonist reported. It has been used to probe the role of V\(_{1b}\) receptors in animal models of depression, aggression, and stress-anxiety, and was progressed to clinical trials for the treatment of depression. Due to the interest in V\(_{1b}\) receptors as a therapeutic target and the growing use of SSR149415 in preclinical research, we developed a method to label SSR145419 with carbon-11 and have studied its pharmacokinetics in non-human primates using positron emission tomography.en-USpositron emission tomographyvasopressinSSR149415carbon-11Journal Article10.1016/j.bmcl.2010.03.108