Gora, Michalina J.Sauk, Jenny S.Carruth, Robert W.Gallagher, Kevin A.Suter, MelissaNishioka, NormanKava, Lauren E.Rosenberg, MireilleBouma, BrettTearney, Guillermo2014-03-012012Gora, Michalina J., Jenny S. Sauk, Robert W. Carruth, Kevin A. Gallagher, Melissa J. Suter, Norman S. Nishioka, Lauren E. Kava, Mireille Rosenberg, Brett E. Bouma, and Guillermo J. Tearney. 2012. “Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure.” Nature medicine 19 (2): 238-240. doi:10.1038/nm.3052. http://dx.doi.org/10.1038/nm.3052.1078-8956http://nrs.harvard.edu/urn-3:HUL.InstRepos:11855924Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut wall as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.en-USJournal Article2014-03-0110.1038/nm.3052