Bradner, James ElliottMcKeown, Michael Robert2014-06-062014-06-062014McKeown, Michael Robert. 2014. Chemical Probes and the Exploration of Bromodomains in Cancer Biology. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11468http://nrs.harvard.edu/urn-3:HUL.InstRepos:12269851The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate their biological actions and to potentially lead to therapeutics. However, these protein-protein interactions have been considered difficult to inhibit and few high-quality chemical probes currently exist for the study of epigenetic biological systems in particular.en-USBiochemistryCellular biologyOncologyBromodomainCancerDLBCLInhibitorLymphomaOncologyThesis or Dissertation2016-06-04