Schreiber, Stuart L.Schaefer, Giannina Ines2014-06-062014-06-062014Schaefer, Giannina Ines. 2014. Small-molecule probes to explore cancer. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11361http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274182Small molecules play important roles in therapeutics and drug discovery. Significant progress has been made by the chemical biology community to discover small-molecule probes to explore biological processes and to treat disease. This thesis describes both the discovery of novel probes for the Hedgehog (Hh) pathway and the application of small molecules in identifying cancer dependencies.en-USChemistryBiochemistrycancercancer dependencieshedgehog signalingsmall-molecule probesThesis or Dissertation2015-06-04