Wirth, Dyann F.Herman, Jonathan D2014-06-062014-06-062014Herman, Jonathan David. 2014. Halofuginone: A Story of How Target Identification of an Ancient Chinese Medicine and Multi-Step Evolution Informs Malaria Drug Discovery. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11540http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274328Malaria is a treatable communicable disease yet remains a common cause of death and disease especially among pregnant women and children. Most of malaria's worldwide burden disproportionately lies in Southeast Asia and Sub-Saharan Africa. Western medicine's 100+ year history of combating Plasmodium falciparum has taught us that the global population of malaria parasites has a unique and dangerous ability to rapidly evolve and spread drug resistance. Recently it was documented that resistance to the first-line antimalarial artemisinin may be developing in Southeast Asia.en-USParasitologyBiologyPublic healthdrug resistanceevolutionhalofuginonemalarianon-genetic adaptationtRNA synthetaseThesis or Dissertation2015-06-04