Myers, Andrew G.Smaltz, Daniel Jonathan2014-06-062014-06-062014Smaltz, Daniel Jonathan. 2014. Component-Based Syntheses of Trioxacarcins. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11551http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274279The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex DNA. This dissertation presents a component-based synthetic route to the trioxacarcin structural class, broadly defined, which resulted in fully synthetic routes to trioxacarcin A (1), DC-45-A1 (10), and a diverse collection of analogs.en-USOrganic chemistryanalogantiproliferativeDC-45-A1glycosylationsynthesistrioxacarcinThesis or Dissertation2014-06-06