Gray, Nathanael SchianderXie, Ting2014-06-062014-06-062014Xie, Ting. 2014. Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11384http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274197With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted with small molecule inhibitors. During the past five years, I have been working on figuring out the path to inhibit two elusive cancer targets: Her3 and KRas.en-USChemistryBiologyBiochemistryHer3KRasThesis or Dissertation