Ripke, StephanO'Dushlaine, ColmChambert, KimberlyMoran, Jennifer LKähler, Anna KAkterin, SusanneBergen, SarahCollins, Ann LCrowley, James JFromer, MenachemKim, YunjungLee, Sang HongMagnusson, Patrik KESanchez, NickStahl, Eli AWilliams, StephanieWray, Naomi RXia, KaiBettella, FrancescoBørglum, Anders DBulik-Sullivan, Brendan KCormican, PaulCraddock, Nickde Leeuw, ChristiaanDurmishi, NaserGill, MichaelGolimbet, VeraHamshere, Marian LHolmans, PeterHougaard, David MKendler, Kenneth SLin, KuangMorris, Derek WMors, OleMortensen, Preben BNeale, BenjaminO'Neill, Francis AOwen, Michael JMilovancevic, MilicaPejovicPosthuma, DaniellePowell, JohnRichards, Alexander LRiley, Brien PRuderfer, DouglasRujescu, DanSigurdsson, EngilbertSilagadze, TeimurazSmit, August BStefansson, HreinnSteinberg, StacySuvisaari, JaanaTosato, SarahVerhage, MatthijsWalters, James TBramon, ElviraCorvin, Aiden PO'Donovan, Michael CStefansson, KariScolnick, EdwardPurcell, ShaunMcCarroll, SteveSklar, PamelaHultman, Christina MSullivan, Patrick F2014-05-062013Ripke, S., C. O'Dushlaine, K. Chambert, J. L. Moran, A. K. Kähler, S. Akterin, S. Bergen, et al. 2013. “Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia.” Nature genetics 45 (10): 10.1038/ng.2742. doi:10.1038/ng.2742. http://dx.doi.org/10.1038/ng.2742.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152923Schizophrenia is a heritable disorder with substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases, 6,243 controls) followed by meta-analysis with prior schizophrenia GWAS (8,832 cases, 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls, and 581 trios). In total, 22 regions met genome-wide significance (14 novel and one previously implicated in bipolar disorder). The results strongly implicate calcium signaling in the etiology of schizophrenia, and include genome-wide significant results for CACNA1C and CACNB2 whose protein products interact. We estimate that ∼8,300 independent and predominantly common SNPs contribute to risk for schizophrenia and that these collectively account for most of its heritability. Common genetic variation plays an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this devastating disorder.en-USschizophreniageneticsgenome-wide associationmeta-analysisJournal Article2014-05-0610.1038/ng.2742