Liu, ShuangAn, JieLin, JianhongLiu, YanliBao, LidaoZhang, WenZhao, Jian-Jun2014-05-062014Liu, Shuang, Jie An, Jianhong Lin, Yanli Liu, Lidao Bao, Wen Zhang, and Jian-Jun Zhao. 2014. “Single Nucleotide Polymorphisms of MicroRNA Processing Machinery Genes and Outcome of Hepatocellular Carcinoma.” PLoS ONE 9 (3): e92791. doi:10.1371/journal.pone.0092791. http://dx.doi.org/10.1371/journal.pone.0092791.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:12153014MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome. Among the 6 SNPs, only the A/A genotype of rs11077 located in XPO5 3′UTR was identified to associated independently with worse survival in HCC patients by multivariate analysis with relative risk, 0.395; 95% CI, 0.167–0.933; p = 0.034. This is the first study reporting that polymorphisms related to miRSNPs have prognostic value in hepatocellular carcinoma and identify the A/A genotype of rs11077 SNP site located in XPO5 3′UTR can help to predict worse prognosis in patients.en-USBiology and life sciencesBiochemistryRNARNA processingCell BiologyMolecular Cell BiologyEvolutionary BiologyPopulation GeneticsGenetic PolymorphismGeneticsHuman GeneticsGenetic Association StudiesCancer GeneticsGene ExpressionPopulation BiologyMedicine and Health SciencesClinical GeneticsEpidemiologyCancer EpidemiologyGastroenterology and HepatologyLiver DiseasesHepatocellular CarcinomaOncologyCancer Risk FactorsGenetic Causes of CancerCancers and NeoplasmsGastrointestinal TumorsJournal Article2014-05-0610.1371/journal.pone.0092791