Masciari, SerenaDewanwala, AkritiStoffel, Elena M.Lauwers, Gregory Y.Zheng, HuiAchatz, Maria IsabelRiegert-Johnson, DouglasForetova, LenkaSilva, Edaise M.Digianni, LisaVerselis, Sigitas J.Schneider, KatherineLi, Frederick PeiFraumeni, JosephGarber, JudySyngal, Sapna2014-07-292011Masciari, Serena, Akriti Dewanwala, Elena M. Stoffel, Gregory Y. Lauwers, Hui Zheng, Maria Isabel Achatz, Douglas Riegert-Johnson, et al. 2011. Gastric cancer in individuals with Li-Fraumeni syndrome. Genetics in Medicine 13(7): 651–657.1098-3600http://nrs.harvard.edu/urn-3:HUL.InstRepos:12602576PURPOSE: Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associated tumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of gastric cancer in Li-Fraumeni syndrome. METHODS: Pedigrees and medical records of 62 TP53 mutation-positive families were retrospectively reviewed from the Dana-Farber/National Cancer Institute Li-Fraumeni syndrome registry. We identified subjects with gastric cancer documented either by pathology report or death certificate and performed pathology review of the available specimens. RESULTS: Among 62 TP53 mutation-positive families, there were 429 cancer-affected individuals. Gastric cancer was the diagnosis in the lineages of 21 (4.9%) subjects from 14 families (22.6%). The mean and median ages at gastric cancer diagnosis were 43 and 36 years, respectively (range: 24-74 years), significantly younger compared with the median age at diagnosis in the general population based on Surveillance Epidemiology and End Results data (71 years). Five (8.1%) families reported two or more cases of gastric cancer, and six (9.7%) families had cases of both colorectal and gastric cancers. No association was seen between phenotype and type/location of the TP53 mutations. Pathology review of the available tumors revealed both intestinal and diffuse histologies. CONCLUSIONS: Early-onset gastric cancer seems to be a component of Li-Fraumeni syndrome, suggesting the need for early and regular endoscopic screening in individuals with germline TP53 mutations, particularly among those with a family history of gastric cancer.en-USLi Fraumeni syndromegastric cancerhereditary gastric cancer syndromesgermline mutationsTP53Journal Article2014-07-2910.1097/GIM.0b013e31821628b6