Sparling, Brian AndrewMoebius, David C.Shair, Matthew2014-07-252013Sparling, Brian A., David C. Moebius, and Matthew D. Shair. 2013. Enantioselective Total Synthesis of Hyperforin. Journal of the American Chemical Society 135, no. 2: 644–647.0002-78631520-5126http://nrs.harvard.edu/urn-3:HUL.InstRepos:12563735A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.en-USJournal Article2014-07-2510.1021/ja312150d