Lu, BoHoogerheide, David PaulZhao, QingZhang, HengbinTang, ZhipengYu, DapengGolovchenko, Jene2014-07-232013Lu, Bo, David P. Hoogerheide, Qing Zhao, Hengbin Zhang, Zhipeng Tang, Dapeng Yu, and Jene A. Golovchenko. 2013. Pressure-Controlled Motion of Single Polymers through Solid-State Nanopores. Nano Letters 13(7): 3048–3052.1530-6984http://nrs.harvard.edu/urn-3:HUL.InstRepos:12559593Voltage-biased solid-state nanopores are well established in their ability to detect and characterize single polymers, such as DNA, in electrolytes. The addition of a pressure gradient across the nanopore yields a second molecular driving force that provides new freedom for studying molecules in nanopores. In this work, we show that opposing pressure and voltage bias enables nanopores to detect and resolve very short DNA molecules, as well as to detect near-neutral polymers.en-USsolid-state nanoporespressure gradientDNA single-molecule detectionnear neutral molecule detectionshort molecule discriminationJournal Article2014-07-2310.1021/nl402052v