Hirschhorn, Joel NaomChan, Ying Leong2014-06-062014-06-062014Chan, Ying Leong. 2014. Leveraging genetic association data to investigate the polygenic architecture of human traits and diseases. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11372http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274191Many human traits and diseases have a polygenic architecture, where phenotype is partially determined by variation in many genes. These complex traits or diseases can be highly heritable and genome-wide association studies (GWAS) have been relatively successful in the identification of associated variants. However, these variants typically do not account for most of the heritability and thus, the genetic architecture remains uncertain.en-USGeneticsBiostatisticsBioinformaticsComplex DiseasesHeightSitting Height RatioThesis or Dissertation2014-12-04