Puigserver, Pere PuigserverHall, Jessica2014-06-062014-06-062014Hall, Jessica Ann. 2014. Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11663http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274577Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, multi-organ effort that integrates hormonal signals with transcriptional regulatory networks. When these relationships are altered, as with over-nutrition and insulin resistance, metabolic disease ensues. Here, I present data concerning two distinct transcriptional pathways--one for thyroid hormone (TH) and one for insulin--that confer hormone responsiveness on metabolic gene programs that preserve energy homeostasis.en-USBiologyCellular biologyMolecular biologybrown adipose tissueglucose metabolisminsulinthermogenesisthyroid hormoneThesis or Dissertation2014-06-06