Fuchs, Michael A.Sato, KaoriNiedzwiecki, DonnaYe, XingSaltz, Leonard B.Mayer, Robert J.Mowat, Rex B.Whittom, RenaudHantel, AlexanderBenson, AlAtienza, DanielMessino, MichaelKindler, HedyVenook, AlanOgino, ShujiWu, KanaWillett, WalterGiovannucci, EdwardMeyerhardt, Jeffrey A.2014-07-072014Fuchs, M. A., K. Sato, D. Niedzwiecki, X. Ye, L. B. Saltz, R. J. Mayer, R. B. Mowat, et al. 2014. “Sugar-Sweetened Beverage Intake and Cancer Recurrence and Survival in CALGB 89803 (Alliance).” PLoS ONE 9 (6): e99816. doi:10.1371/journal.pone.0099816. http://dx.doi.org/10.1371/journal.pone.0099816.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406571Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming ≥2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04–2.68), compared with those consuming <2 servings per month (Ptrend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥25 kg/m2) and less physically active (metabolic equivalent task-hours per week <18) (HR = 2.22; 95% CI, 1.29–3.81, Ptrend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.en-USMedicine and Health SciencesEpidemiologyCancer EpidemiologyOncologyCancers and NeoplasmsColorectal CancerJournal Article2014-07-0710.1371/journal.pone.0099816