Schwarzkopf, RanMikhael, BassemWright, ElizabethEstok, DanielKatz, Jeffrey2014-07-072014Schwarzkopf, Ran, Bassem Mikhael, Elizabeth Wright, Daniel M Estok, and Jeffrey N Katz. 2014. “Treatment Failure Among Infected Periprosthetic Total Hip Arthroplasty Patients.” The Open Orthopaedics Journal 8 (1): 118-124. doi:10.2174/1874325020140515002. http://dx.doi.org/10.2174/1874325020140515002.1874-3250http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406577Two-stage revision has been shown to be the most successful treatment in eradicating deep infection following total hiparthroplasty. We identified 62 patients treated by a two-stage revision. We defined “successful revision” as negative intraoperative cultures and no further infection-related procedure. We defined “eradication of infection” on the basis of negative cultures and clinical diagnosis at least one year after 2nd stage procedure. After a mean follow up of 2.7 years, eradication of the infection was documented in 91.1%, and a successful two-stage revision in 85.7% of patients. We observed no association between higher pre-reimplantation levels of ESR and C-reactive protein and lower likelihood of successful two-stage revision. We found an association between a history of another previous infected prosthetic joint and a failed 2nd stage procedure. Failure to achieve eradication of infection and successful two-stage revision occurs infrequently. Patients with prior history of a previous prosthetic joint infection are at higher risk of failure.en-USHip arthroplastymodular antibiotic cement spacerperiprosthetic infectiontwo-stage revision surgery.Journal Article2014-07-0710.2174/1874325020140515002