Braunstein, LiorChen, Ming-HuiLoffredo, MarianKantoff, Philip W.D'Amico, Anthony V.2014-07-072014Braunstein, Lior Z., Ming-Hui Chen, Marian Loffredo, Philip W. Kantoff, and Anthony V. D'Amico. 2014. “Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer.” Prostate Cancer 2014 (1): 230812. doi:10.1155/2014/230812. http://dx.doi.org/10.1155/2014/230812.2090-3111http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406838Background:. Increasing body mass index (BMI) is associated with increased risk of mortality; however, quantifying weight gain in men undergoing androgen deprivation therapy (ADT) for prostate cancer (PC) remains unexplored. Methods. Between 1995 and 2001, 206 men were enrolled in a randomized trial evaluating the survival difference of adding 6 months of ADT to radiation therapy (RT). BMI measurements were available in 171 men comprising the study cohort. The primary endpoint was weight gain of ≥10 lbs by 6-month followup. Logistic regression analysis was performed to assess whether baseline BMI or treatment received was associated with this endpoint adjusting for known prognostic factors. Results. By the 6-month followup, 12 men gained ≥10 lbs, of which 10 (83%) received RT + ADT and, of these, 7 (70%) were obese at randomization. Men treated with RT as compared to RT + ADT were less likely to gain ≥10 lbs (adjusted odds ratio (AOR): 0.18 [95% CI: 0.04–0.89]; P = 0.04), whereas this risk increased with increasing BMI (AOR: 1.15 [95% CI: 1.01–1.31]; P = 0.04). Conclusions. Consideration should be given to avoid ADT in obese men with low- or favorable-intermediate risk PC where improved cancer control has not been observed, but shortened life expectancy from weight gain is expected.en-USJournal Article2014-07-0710.1155/2014/230812