Tanguturi, ShyamChen, Ming-HuiLoffredo, MarianRichie, Jerome P.D'Amico, Anthony V.2014-07-072014Tanguturi, Shyam K., Ming-Hui Chen, Marian Loffredo, Jerome P. Richie, and Anthony V. D'Amico. 2014. “Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort.” Prostate Cancer 2014 (1): 395078. doi:10.1155/2014/395078. http://dx.doi.org/10.1155/2014/395078.2090-3111http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406868Purpose. We investigated whether NS-RP increased risk of PSA failure and whether PSA should be included as a selection criterion for NS. Methods:. We evaluated 357 consecutive men with screen-detected PC who underwent open RP without adjuvant radiotherapy between 9/11/2001 and 12/30/2008. Criteria for NS included Gleason score ≤3 + 4, percentage of positive biopsies (PPB) ≤50%, percentage of core involvement ≤50%, nonapical location, no perineural invasion, and no palpable disease on pre- or intraoperative exam but did not include a PSA threshold. Cox multivariable regression assessed whether increasing PSA or unilateral- or bilateral-NS versus non-NS-RP was associated with PSA failure adjusting for prognostic factors. Results:. After a median follow-up of 3.96 years, 34 men sustained PSA failure (9.5%). Increasing PSA was significantly associated with increased risk of PSA failure in the interaction model (adjusted hazard ratio (AHR): 1.09 [95% CI: 1.03–1.16]; P = 0.005), whereas unilateral (AHR: 1.24 [95% CI: 0.36–4.34]; P = 0.73) or bilateral NS (AHR: 0.41 [95% CI: 0.06–2.59]; P = 0.34) versus non-NS RP was not. Conclusion:. NS-RP in a screened cohort did not increase risk of PSA failure using NS criteria not including PSA.en-USJournal Article2014-07-0710.1155/2014/395078